摘要: |
利用4-二乙氧基膦酰基-2-酮丁酸乙酯与 L-赤式-(+)-1,乙-二苯基-2-氨基乙醇的缩合,将产物还原、氢解及水解得光活性产物,ee 值67%。 |
关键词: 不对称合成 4-二乙氧基膦酰基-2-酮丁酸乙酯 S( )-2-氨基-4-膦酸基丁酸 |
DOI: |
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基金项目: |
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A NOVEL ASYMMETRIC SYNTHESIS OF S(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID |
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Abstract: |
A novel asymmetric synthetic route to s(+)-2-amino-4-phospho- nobutyric acid through the cyclic condensation of ethyl-4-diethylphosphonyl-2- oxo-butanoate with erythro L(+)-1,2-diphenyl-2-aminoethanol,followed by reduction and hydrolysis is described. |
Key words: asymmetrc synthesis ethyl-4-diethoxy phosphonyl-2-oxo-but-anoates s( )-2-amino-4-phosphono-butanoic acid |